Dendrite pruning1/27/2024 Kano M, Hashimoto K (2012) Activity-dependent maturation of climbing fiber to Purkinje cell synapses during postnatal cerebellar development. Koleske AJ (2013) Molecular mechanisms of dendrite stability. Cold Spring Harb Perspect Biol 2:a001750ĭeFelipe J (2015) The dendritic spine story: an intriguing process of discovery. Grueber WB, Sagasti A (2010) Self-avoidance and tiling: mechanisms of dendrite and axon spacing. Annu Rev Neurosci 32:347–381Ĭraig AM, Banker G (1994) Neuronal polarity. Thousand-and-one-amino acid 2 kinase TrkB:īarnes AP, Polleux F (2009) Establishment of axon-dendrite polarity in developing neurons. Ras-related C4 botulinum toxin substrate 1 Ret: Myristoylated alanine-rich C-kinase substrate MEF: Α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor ASD:Ĭa 2+/calmodulin-dependent protein kinase CaMKK:Ĭa 2+/calmodulin-dependent protein kinase kinase CBP:ĬAMP-response element binding protein DSCAM:ĭown syndrome cell adhesion molecule ERK:Įxtracellular signal-regulated kinases FMRP:įragile X mental retardation protein GAP: Additionally, we briefly comment on the implications of aberrant dendritic morphology for nervous system disease. We focus on different aspects of vertebrate dendrite patterning that are particularly important in determining the neuronal function such as the shape, branching, orientation and size of the arbors as well as the development of dendritic spine protrusions that receive excitatory inputs and compartmentalize postsynaptic responses. Here, we summarize the molecular and cellular mechanisms that regulate the formation of cell type-specific dendrite patterns during development. To ensure proper neuronal function and connectivity, it is necessary that dendrite patterns are precisely controlled and coordinated with These neuron-specific morphologies determine how dendritic trees integrate thousands of synaptic inputs to generate different firing properties. Let us know how this access is important for you.The nervous system is populated by diverse types of neurons, each of which has dendritic trees with strikingly different morphologies. Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Therefore, understanding the mechanisms of axon and dendritic pruning will be instrumental in advancing our knowledge of neural disease and mental disorders. Disruption of these mechanisms results in abnormal pruning, which has been linked to brain dysfunction. Owing to the importance of axon and dendritic pruning, these remodeling events require precise spatial and temporal control, and this is achieved by a range of distinct molecular mechanisms. In many instances, these developmental processes are regulated by the interplay between neurons and glial cells that act instructively during neural remodeling. Most axon pruning involves the removal of axons that had already made synaptic connections thus, axon pruning is tightly associated with synapse elimination. Regressive events encompass a variety of inhibitory developmental processes, including axon and dendrite pruning, which facilitate the removal of exuberant neuronal connections. The assembly of functional neural circuits requires the combined action of progressive and regressive events.
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